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tadalafil increases effects of atenolol by pharmacodynamic synergism. azilsartantadalafil increases effects of azilsartan by pharmacodynamic synergism. tadalafil increases effects of azilsartan by pharmacodynamic synergism.
Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. If unavoidable, reduce CYP3A substrate dose according to product labeling. tucatinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. acebutololtadalafil increases effects of acebutolol by pharmacodynamic synergism. tadalafil increases effects of acebutolol by pharmacodynamic synergism.
acetazolamidetadalafil increases effects of acetazolamide by pharmacodynamic synergism. tadalafil increases effects of acetazolamide by pharmacodynamic synergism. alfuzosintadalafil increases effects of alfuzosin by pharmacodynamic synergism. tadalafil increases effects of alfuzosin by pharmacodynamic synergism. aliskirentadalafil increases effects of aliskiren by pharmacodynamic synergism. benazepriltadalafil increases effects of benazepril by pharmacodynamic synergism. tadalafil increases effects of benazepril by pharmacodynamic synergism. betaxololtadalafil increases effects of betaxolol by pharmacodynamic synergism. tadalafil increases effects of betaxolol by pharmacodynamic synergism.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Cialis Professional | 20mg | 360 + 6 Pills | 807.03€ 768.60€ | |
| Cialis Generic | 5mg | 360 + 10 Pills | 268.08€ 255.31€ | |
| Cialis Soft Tabs | 20mg | 120 + 6 Pills | 248.64€ 236.80€ | |
| Cialis Professional | 40mg | 60 + 2 Pills | 262.32€ 249.83€ | |
| Cialis Generic | 40mg | 90 + 6 Pills | 171.35€ 163.19€ | |
| Cialis Generic | 10mg | 60 + 6 Pills | 105.81€ 100.77€ | |
| Cialis Generic | 40mg | 270 + 10 Pills | 382.19€ 363.99€ | |
| Cialis Soft Tabs | 20mg | 90 + 6 Pills | 216.71€ 206.39€ | |
| Cialis Super Active | 20mg | 180 + 20 Pills | 521.59€ 496.75€ | |
| Cialis Black | 80mg | 270 + 10 Pills | 502.88€ 478.93€ | |
| Cialis Generic | 20mg | 180 + 10 Pills | 254.09€ 241.99€ | |
| Cialis Super Active | 20mg | 270 + 30 Pills | 661.49€ 629.99€ | |
| Cialis Black | 80mg | 20 Pills | 71.83€ 68.41€ | |
| Cialis Generic | 2.5mg | 20 Pills | 40.73€ 38.79€ |
bicalutamidebicalutamide will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. bicalutamide will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. bisoprololtadalafil increases effects of bisoprolol by pharmacodynamic synergism. tadalafil increases effects of bisoprolol by pharmacodynamic synergism. bosentanbosentan will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. bosentan will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
asenapinetadalafil increases effects of asenapine by pharmacodynamic synergism. tadalafil increases effects of asenapine by pharmacodynamic synergism. atazanaviratazanavir increases levels of tadalafil by decreasing metabolism. atazanavir increases levels of tadalafil by decreasing metabolism. atenololtadalafil increases effects of atenolol by pharmacodynamic synergism. budesonidebudesonide will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
| Country | Legal Status | Notes |
|---|---|---|
| USA | Over-the-counter or prescription | Prescription required for 20 mg dose |
| UK | Prescription only | Available via doctor’s prescription |
| Canada | Prescription needed | Can be obtained with a doctor's script |
| Australia | Prescription-only | Legal for treatment of ED |
| India | Over-the-counter / prescription | Widely available, some formulations sold without prescription |
budesonide will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
| Study | Sample Size | Effectiveness Rate | Notes |
|---|---|---|---|
| Smith et al., 2021 | 500 patients | 85% achieved satisfactory erection | Most patients reported positive results |
| Lee et al., 2020 | 300 patients | 88% reported improved erectile function | Effective within 30-60 minutes |
| Kumar et al., 2019 | 200 patients | 82% experienced side effects | Mild to moderate side effects in some |
bumetanidetadalafil increases effects of bumetanide by pharmacodynamic synergism. tadalafil increases effects of bumetanide by pharmacodynamic synergism. bumetanide intranasaltadalafil increases effects of bumetanide intranasal by pharmacodynamic synergism.
tadalafil increases effects of aliskiren by pharmacodynamic synergism. Monitor blood pressure response to phosphodiesterase type 5 (PDE5) inhibitors in patients receiving concurrent blood pressure lowering therapy. amiloridetadalafil increases effects of amiloride by pharmacodynamic synergism. tadalafil increases effects of amiloride by pharmacodynamic synergism. amiodaroneamiodarone will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
CYP3A4 inhibitors may reduce tadalafil clearance increasing systemic exposure to tadalafil; increased levels may result in increased associated adverse events. amiodarone will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. amlodipinetadalafil increases effects of amlodipine by pharmacodynamic synergism. tadalafil increases effects of amlodipine by pharmacodynamic synergism. aprepitantaprepitant will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tadalafil increases effects of bumetanide intranasal by pharmacodynamic synergism. butalbitalbutalbital will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
| Side Effect | Frequency | Severity | Recommendations |
|---|---|---|---|
| Headache | Common | Mild | Use over-the-counter pain relief |
| Flushing | Common | Mild | Hydrate and avoid extreme temperatures |
| Indigestion | Less common | Mild | Avoid heavy or greasy meals |
| Muscle aches | Occasional | Mild | Rest and hydration |
| Vision changes | Rare | Moderate | Seek medical attention if severe |
butalbital will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. candesartantadalafil increases effects of candesartan by pharmacodynamic synergism.
tadalafil increases effects of candesartan by pharmacodynamic synergism. captopriltadalafil increases effects of captopril by pharmacodynamic synergism.
aprepitant will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. armodafinilarmodafinil will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. armodafinil will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. artemether/lumefantrineartemether/lumefantrine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. artemether/lumefantrine will decrease the level or effect of tadalafil by 10mg cialis price affecting hepatic/intestinal enzyme CYP3A4 metabolism. tadalafil increases effects of captopril by pharmacodynamic synergism. carbamazepinecarbamazepine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. For patients with ED, monitor response to tadalafil carefully because of potential for decreased effectiveness.
carbamazepine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. carvediloltadalafil increases effects of carvedilol by pharmacodynamic synergism. tadalafil increases effects of carvedilol by pharmacodynamic synergism. cenobamatecenobamate will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate.
idelalisibidelalisib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates idelalisib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. itraconazole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ketoconazoleketoconazole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. CYP3A4 inhibitors may reduce tadalafil clearance increasing systemic exposure to tadalafil; significantly increased levels may result in significant adverse events including severe hypotension, syncope, visual changes, and priapism.
ketoconazole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lenacapavirlenacapavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Refer to the prescribing information of PDE5 inhibitors for dose recommendations. lenacapavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. levoketoconazolelevoketoconazole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cenobamate will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
levoketoconazole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lonafarniblonafarnib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling. lonafarnib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lopinavirlopinavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
lopinavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nelfinavirnelfinavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nelfinavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nicardipinenicardipine will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nicardipine will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. chlorthalidonetadalafil increases effects of chlorthalidone by pharmacodynamic synergism.
Avoid coadministration if tadalafil used for pulmonary arterial hpertension. Reduce tadalafil dose if used for erectile dysfunction. nirmatrelvir/ritonavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ritonavirritonavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ritonavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
tovorafenibtovorafenib will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration of tovorafenib (a weak CYP3A4 inducer) with CYP3A substrates where minimal concentration changes may lead to serious therapeutic failures. If unavoidable, monitor patients for loss of efficacy unless otherwise recommended in the CYP3A4 substrate prescribing information. tovorafenib will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tucatinibtucatinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tadalafil increases effects of chlorthalidone by pharmacodynamic synergism.